TAXOL - (33069-62-4)

परिचय

नाम: Taxol; paclitaxel; (2α,4α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
* IUPAC
सीएएस संख्या: 33069-62-4
रासायनिक सूत्र: C47H51NO14
अणु भार: 853.90614 g
मास प्रतिशत: C 66.108 %; H 6.0199 %; N 1.6403 %; O 26.231 % 

वर्गीकरण

उपयोग करता है / समारोह

• "...has a significant activity against several forms of cancer, especially ovarian cancer...Some anticancer drugs kill cancerous cells without acting on DNA. Certain alkaloids, such as vincristine, and taxol, kill dividing cells by preventing the formation of cellular microstructures needed for division." 1

• "Tool in study of structure and function of microtubules. Antineoplastic." 2

भौतिक गुण

गलनांक:*
214°C †3 = 487.15 K = 417.2°F


* - 1 atm pressure
† - मिटता

संबंध

डबल बांड: 15
ट्रिपल बांड: 0
सिग्मा बांड: 119
गड़बड़ी बांड: 15
कुल: 134
carboxyl समूहों: 0
हाइड्रॉक्सिल समूहों: 3

अधिक जानकारी के लिए

विकिपीडिया
जर्नल्स:
M. C. Wani et. al., J. Am. Chem. Soc. 93, 2325 (1971)
P. B. Schiff et. al., Nature 277, 665 (1979)
G. Chauviere et. al., C.R. Acad. Sci. Paris Ser. II 293, 501 (1981)
R. A. Holton et. al., J. Am. Chem. Soc. 110, 6558 (1988)
K. C. Nicolaou et. al., Nature 367, 630 (1994)
A. Stierle et. al., Science 260, 241 (1993)
M. W. Saville et. al., Lancet 346, 26 (1995)
J. J. Manfredi, S. B. Horwitz, Pharmacol. Ther. 25, 83-125 (1984)
S. B. Horwitz et. al., Ann. N.Y. Acad. Sci. 466, 733-744 (1986)
S. B. Horwitz, Trends Pharmacol. Sci. 13, 134-136 (1992)
C. D. Runowicz et. al., Cancer 71, 1591-1596 (1993)

सूत्रों का कहना है

(1) - Suchocki, John. Conceptual Chemistry: Understanding Our World of Atoms and Molecules; Addison Wesley: San Francisco, California, 2001; pp 441, 450.
(2) - The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 13th ed.; Budavari, S.; O'Neil, M.J.; Smith, A.; Heckelman, P. E.; Kinneary, J. F., Eds.; Merck & Co.: Whitehouse Station, NJ, 2001; entry 7052.
(3) - Lide, David R. CRC Handbook of Chemistry and Physics, 84th ed.; CRC Press: Boca Raton, FL, 2003; p 3-508.