IBUPROFEN - (15687-27-1)

Giới thiệu

Tên: ibuprofen; (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid*; 2-(4-isobutylphenyl)propionic acid
* IUPAC
Số CAS: 15687-27-1
Công thức hóa học: C13H18O2
Khối lượng phân tử: 206.28082 g
Lễ Percent: C 75.692 %; H 8.7952 %; O 15.512 % 

phân loại

Sử dụng / Chức năng

• "Ibuprofen is a nonsteroidal anti-inflammatory drug, or NSAID. The term nonsteroidal indicates that ibuprofen is not a steroid, a common class of drugs used to reduce inflammation and swelling. Scientists believe that ibuprofen works by inhibiting cyclooxygenase (COX) which converts arachidonic acid to prostaglandins. Arachidonic acid is a naturally occurring fatty acid that is used to build a number of important biochemical compounds, including the prostaglandins. The prostaglandins are involved in the transmission of pain impulses throughout the nervous system. If the COX enzyme is prevented from functioning, arachidonic acid can not be converted into prostaglandins and pain messages will not be transmitted. Ibuprofen is especially effective in treating certain kinds of pain and inflammation, including those associated with menstrual cramps, various kinds of arthritis, headaches and migraines, pain from injuries and surgery, and discomfort associated with influenza and gout. The major risk associated with use of ibuprofen is stomach irritation. The inventors of ibuprofen has hoped to find a substance that causes less stomach irritation than aspirin. Ibuprofen does seem to cause fewer gastrointestinal problems than does aspirin. Nevertheless, it can still cause severe problems in some patients, especially those who take large doses. Common complaints from the use of ibuprofen include nausea, stomach pain, and diarrhea. Patients who are especially sensitive or who take high doses of ibuprofen for long periods may experience damage to the stomach lining. As with any drug, some patients should avoid taking ibuprofen entirely. These include individuals with heart or kidney problems, people who are taking so-called ‘blood thinners,’ pregnant women during the last three months of pregnancy, people with asthma, and people who are allergic to aspirin." 1

bonding

Trái phiếu tăng gấp đôi: 4
Trái phiếu ba: 0
Trái phiếu Sigma: 33
Trái phiếu Pi: 4
Tổng số: 37
carboxyl Groups: 1
hydroxyl Groups: 0
lai: aromatic and carboxyl carbons are sp2; other carbons are sp3; double bonded oxygen is sp2; single bonded oxygen is sp3

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nguồn

(1) - Schlager, Neil, Weisblatt, Jayne, Newton, David E., and Montney, Charles B. Chemical Compounds Vol. 1; Thomson-Gale: Detroit, MI, 2006; pp 11-13.