Name: cisplatin; (SP-4-2)-diamminedichloridoplatinum; cis-diamminedichloroplatinum(II)
CAS Number: 15663-27-1
Molar Mass: 300.04504 g
Mass Percent: H 2.0155 %; Cl 23.631 %; N 9.3363 %; Pt 65.016 %
• "Cisplatin is one of the top three chemotherapeutics, used as a first-line treatment for most malignancies. It works by causing cross-links to form between nucleotide bases in the DNA of cancer cells, leading to mayhem during replication and translation, rapidly followed by cell death." 1
• "Harsher [anticancer] agents [than 5-fluorouracil, such as cyclophosphamide and cisplatin...destroy DNA's ability to function by chemically bonding to the DNA or by cross-linking the two strands of the double helix." 2
For More Information
(1) - Ryan, Morgan. Rationally Engineering Chemo. American Scientist. 2010, 98, 466.
(2) - Suchocki, John. Conceptual Chemistry: Understanding Our World of Atoms and Molecules; Addison Wesley: San Francisco, California, 2001; p 450.