Name: sarin; 2-(fluoro-methylphosphoryl)oxypropane; (RS)-propan-2-yl methylphosphonofluoridate
CAS Number: 107-44-8
Molar Mass: 140.0931642 g
State of Matter: clear, colorless liquid
Mass Percent: C 34.293 %; H 7.1947 %; F 13.561 %; O 22.841 %; P 22.109 %
• "Isopropylmethylphosphonofluoridate. An extremely toxic nerve gas." 1
• "Sarin, like other nerve agents, interferes with the process by which nerve cells communicate with each other, disrupting muscle movement, and other processes the nervous system controls...Normally certain nerve cells communicate via a chemical messenger called acetylcholine, which passes from one cell to another, in this case stimulating muscle contraction. The process is regulated by a protein called acetylcholinesterase, which degrades acetylcholine. This prevents too much acetylcholine from building up and keeps nerve signals firing at a healthy pace. Sarin blocks acetylcholinesterase, causing a flood of acetylcholine that produces constant nerve stimulation. Muscles become fatigued, disrupting normal functions such as breathing...Estimated dose at which 50% of affected population will die through skin exposure is 1700 mg per person." 2
Double Bonds: 1
Triple Bonds: 0
Sigma Bonds: 18
Pi Bonds: 1
Carboxyl Groups: 0
Hydroxyl Groups: 0
NFPA 704 Ratings:
Health: 4 - Very short exposure could cause death or major residual injury.
Flammability: 1 - Must be heated before ignition can occur. Flash point over 93°C (200°F).
Reactivity: 0 - Normally stable, even under fire exposure conditions, and is not reactive with water.
For More Information
(1) - Taber's Cyclopedic Medical Dictionary, 18th ed.; F. A. David Company: Philadelphia, PA, 1997; p 1712
(2) - Barnes, Julian E. and Abi-Habib, Maria, Sarin Use Deifes Chemical-Weapons Deal. Wall Street Journal, April 7, 2017, p A6.